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Senior/Scientist, Cell Line Development

We are seeking an experienced and highly motivated Scientist with strong hands-on experience in developing cell lines to achieve high levels of recombinant antibody expression and in transferring processes to a manufacturing group to produce high quality antibodies. The successful candidate will be self-motivated, enthusiastic, hard-working, detail-oriented, and able to work in a fast-paced environment.

Responsibilities:

  • Contribute to the design, execution and analysis of studies to generate cell lines and to narrow selection of candidate clones during the development process
  • Manage data from clone screening studies and from automation systems used in cell line development
  • Provide continued support for cell line development projects within Discovery

Requirements:

  • PhD with 3-7 years, or MS with 5-10 years of experience in Cell Biology, Molecular Biology, Biochemical Engineering, Chemical Engineering or related Scientific/Engineering field
  • Strong background in mammalian cell culture
  • Experience with suspension culture of CHO cell lines and small scale bioreactor operation in a pharmaceutical or biotechnology setting
  • Strong scientific and engineering expertise optimizing mammalian cell lines and expression technologies for the generation of monoclonal antibodies and recombinant protein therapeutics
  • Strong understanding of mammalian cellular physiology and mammalian expression systems
  • Expertise working with a variety of cell lines and mammalian expression systems, including CHO and NS0
  • Expertise performing antibody characterization activities including ELISA, SDS-PAGE, western blot, and Bio-Layer Interferometry (ForteBio Octet)
  • Strong written and verbal communication skills
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