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Senior Scientist, Antibody Display Technology

We are seeking an experienced and highly motivated Scientist with strong hands-on experience in antibody display (phage/yeast) to support discovery research projects by screening to identify lead candidate therapeutic antibodies, as well as engineering molecules for improved function. The successful candidate will be self-motivated, enthusiastic, hard-working, detail-oriented, and able to work in a fast-paced environment.

Responsibilities:

  • Drive efforts to isolate, clone, build, and optimize therapeutic candidates using phage/yeast display technology
  • Construct libraries for affinity and stability maturation
  • Use automated technologies for processing samples (QPix, TECAN, iQue)
  • Execute protein binding assays such as ELISA, FACS, and Bio-Layer Interferometry (ForteBio Octet) in a high-throughput format
  • Express, purify, and characterize antibodies in biochemical and functional assays (e.g., affinity, activity)
  • Record and capture all necessary data for internal use and IND filings

Requirements:

  • PhD with 3-7 years, or MS with 5-10 years of experience in Molecular Biology, Biochemistry, Immunology or related discipline
  • Experience isolating RNA from immunized animals; constructing phage/yeast libraries; panning/sorting; and evaluating antibody clones
  • Experience designing and executing selection/screening strategies to isolate high affinity antibodies that meet pre-defined criteria, such as species cross-reactivity or biological function
  • Strong written and verbal communication skills
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